The dynamic processes of mitochondrial fusion and fission determine the shape of mitochondria, which can range from individual fragments to a hyperfused network, and influence mitochondrial function. Changes in mitochondrial shape can occur rapidly, allowing mitochondria to adapt to specific cues and changing cellular demands. Here, we will review what is known about how key proteins required for mitochondrial fusion and fission are regulated by their acetylation status, with acetylation promoting fission and deacetylation enhancing fusion. In particular, we will examine the roles of NAD+ dependant sirtuin deacetylases, which mediate mitochondrial acetylation, and how this post-translational modification provides an exquisite regulatory mechanism to co-ordinate mitochondrial function with metabolic demands of the cell.
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December 2021
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Fuelled by the ‘resolution revolution’, cryo-EM has transformed our molecular understanding of transcriptional regulation in bacteria. As an example, Wood and colleagues (pp. 2695–2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. “E. coli Bacteria” by NIAID is licensed under CC BY 2.0. Cover artwork courtesy of Christopher Horne.
Review Article|
November 23 2021
The role of protein acetylation in regulating mitochondrial fusion and fission
Golam M. Uddin;
Golam M. Uddin
Departments of Medical Genetics and Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Rafa Abbas;
Rafa Abbas
Departments of Medical Genetics and Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Timothy E. Shutt
Departments of Medical Genetics and Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Correspondence: Timothy Shutt (timothy.shutt@ucalgary.ca)
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Publisher: Portland Press Ltd
Received:
September 10 2021
Revision Received:
October 20 2021
Accepted:
October 27 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (6): 2807–2819.
Article history
Received:
September 10 2021
Revision Received:
October 20 2021
Accepted:
October 27 2021
Citation
Golam M. Uddin, Rafa Abbas, Timothy E. Shutt; The role of protein acetylation in regulating mitochondrial fusion and fission. Biochem Soc Trans 17 December 2021; 49 (6): 2807–2819. doi: https://doi.org/10.1042/BST20210798
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