The ubiquitin proteasome system (UPS) serves as the major posttranslational modification system for the maintenance of protein homeostasis. The ubiquitin ligases (E3s) are responsible for the recognition and recruitment of specific substrate proteins for polyubiquitination. Really interesting new gene (RING) finger E3s account for the majority of E3s. The human genome encodes more than 600 RING E3s, which are divided into three subclasses: single polypeptide E3s, cullin-RING ligases (CRLs) and other multisubunit E3s. The abnormal regulation of RING E3s has been reported to disrupt normal biological processes and induce the occurrence of many human malignancies. Glioma is the most common type of malignant primary brain tumor. In the last few decades, patient prognosis has improved as novel targeted therapeutic agents have developed. In this review, we will summarize the current knowledge about the dysregulation of RING E3s and the altered stability of their substrates in glioma. We will further introduce and discuss the current status and future perspectives of the application of small inhibitors and proteolysis-targeting chimeric molecules (PROTACs) interfering with RING E3s as potential anticancer agents for glioma.
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February 2021
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On the implications of the copper co-factor in lytic polysaccharide monooxygenase. A brief overview of structure, oxygen activation and application as bioindustrial process tools for decomposition of lignocellulose. Further information can be found in the review by Ipsen and colleagues (pages 531–540). Image provided by Katja Johansen.
Review Article|
February 05 2021
Recent insight into the role of RING-finger E3 ligases in glioma
Yang Cao;
Yang Cao
*
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Hang Zhou;
Hang Zhou
*
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Xiaoyu Chen;
Xiaoyu Chen
*
2Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Yin Li;
Yin Li
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Junwen Hu;
Junwen Hu
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Guoyang Zhou;
Guoyang Zhou
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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Lin Wang
1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Correspondence: Lin Wang (dr_wang@zju.edu.cn)
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Publisher: Portland Press Ltd
Received:
October 30 2020
Revision Received:
January 07 2021
Accepted:
January 12 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (1): 519–529.
Article history
Received:
October 30 2020
Revision Received:
January 07 2021
Accepted:
January 12 2021
Citation
Yang Cao, Hang Zhou, Xiaoyu Chen, Yin Li, Junwen Hu, Guoyang Zhou, Lin Wang; Recent insight into the role of RING-finger E3 ligases in glioma. Biochem Soc Trans 26 February 2021; 49 (1): 519–529. doi: https://doi.org/10.1042/BST20201060
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