The endothelium acts as a gatekeeper, controlling the movement of biomolecules between the circulation and underlying tissues. Although conditions of metabolic stress are traditionally considered as causes of endothelial dysfunction, a principal driver of cardiovascular disease, accumulating evidence suggests that endothelial cells are also active players in maintaining local metabolic homeostasis, in part, through regulating the supply of metabolic substrates, including lipids and glucose, to energy-demanding organs. Therefore, endothelial dysfunction, in terms of altered trans-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within the vascular and metabolism fields that may offer an opportunity for identifying novel therapeutic targets. This mini-review summarises the emerging mechanisms regulating the trafficking of lipids and glucose through the endothelial barrier and how this may impact on the development of cardio-metabolic disease.
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February 2021
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On the implications of the copper co-factor in lytic polysaccharide monooxygenase. A brief overview of structure, oxygen activation and application as bioindustrial process tools for decomposition of lignocellulose. Further information can be found in the review by Ipsen and colleagues (pages 531–540). Image provided by Katja Johansen.
Review Article|
February 22 2021
Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease
Ashton Faulkner
School of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.
Correspondence: Ashton Faulkner (ashton.faulkner@bristol.ac.uk)
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Publisher: Portland Press Ltd
Received:
January 12 2021
Revision Received:
February 01 2021
Accepted:
February 02 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (1): 507–517.
Article history
Received:
January 12 2021
Revision Received:
February 01 2021
Accepted:
February 02 2021
Citation
Ashton Faulkner; Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease. Biochem Soc Trans 26 February 2021; 49 (1): 507–517. doi: https://doi.org/10.1042/BST20200991
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