Leishmaniasis is a vector-borne Neglected Tropical Disease (NTD) transmitted by the sand fly and is a major public health problem worldwide. Infections caused by Leishmania clinically manifest as a wide range of diseases, such as cutaneous (CL), diffuse cutaneous (DCL), mucosal (MCL) and visceral leishmaniasis (VL). The host innate and adaptative immune responses play critical roles in the defense against leishmaniasis. However, Leishmania parasites also manipulate the host immune response for their survival and replication. In addition, other factors such as sand fly salivary proteins and microbiota also promote disease susceptibility and parasite spread by modulating local immune response. Thus, a complex interplay between parasite, sand fly and the host immunity governs disease severity and outcome. In this review, we discuss the host immune response during Leishmania infection and highlight the factors associated with resistance or susceptibility.
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February 2021
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On the implications of the copper co-factor in lytic polysaccharide monooxygenase. A brief overview of structure, oxygen activation and application as bioindustrial process tools for decomposition of lignocellulose. Further information can be found in the review by Ipsen and colleagues (pages 531–540). Image provided by Katja Johansen.
Review Article|
January 15 2021
Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis
Thalia Pacheco-Fernandez;
Thalia Pacheco-Fernandez
*
1Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, U.S.A
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Greta Volpedo;
Greta Volpedo
*
1Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, U.S.A
2Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, U.S.A
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Chaitenya Verma;
Chaitenya Verma
*
1Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, U.S.A
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Abhay R. Satoskar
1Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, U.S.A
2Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, U.S.A
Correspondence: Abhay R. Satoskar (Abhay.Satoskar@osumc.edu)
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Publisher: Portland Press Ltd
Received:
October 28 2020
Revision Received:
December 18 2020
Accepted:
December 23 2020
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (1): 297–311.
Article history
Received:
October 28 2020
Revision Received:
December 18 2020
Accepted:
December 23 2020
Citation
Thalia Pacheco-Fernandez, Greta Volpedo, Chaitenya Verma, Abhay R. Satoskar; Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis. Biochem Soc Trans 26 February 2021; 49 (1): 297–311. doi: https://doi.org/10.1042/BST20200606
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