Extracellular vesicles (EV) are implicated in a variety of functions affecting the extracellular matrix (ECM), including matrix degradation, cross-linking of matrix proteins and matrix calcification. These processes are important in many physiological contexts such as angiogenesis and wound healing, and dysregulation of ECM homeostasis contributes to a wide range of diseases including fibrosis, cancer and arthritis. Most studies of EV have focussed on their roles in cell:cell communication, but EV can exist as integral components of the ECM. By far the most well-characterised ECM-resident EV are matrix vesicles (MV) in bone, but the broader role of EV in the ECM is not well understood. This review will explore what is known of the roles of EV in the ECM and will also highlight the similarities and differences between MV and other EV.
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October 2020
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Cover Image
Centrosomes are microtubule-organizing centres required for the asymmetric division of neural stem cells, which support neurodevelopment, as discussed in a mini-review by Robinson and colleagues (pages 2101–2115) In the cover image, microtubules are shown in yellow and neural stem cells (aPKC) are magenta. Image provided by Dorothy Lerit.
Review Article|
October 14 2020
Extracellular vesicles and the extracellular matrix: a new paradigm or old news?
Samuel Lewin;
Samuel Lewin
1Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
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Stuart Hunt;
Stuart Hunt
2School of Clinical Dentistry, University of Sheffield, Sheffield, U.K.
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Daniel W. Lambert
2School of Clinical Dentistry, University of Sheffield, Sheffield, U.K.
Correspondence: Daniel W. Lambert (d.w.lambert@sheffield.ac.uk)
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Publisher: Portland Press Ltd
Received:
August 03 2020
Revision Received:
September 14 2020
Accepted:
September 16 2020
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2020
Biochem Soc Trans (2020) 48 (5): 2335–2345.
Article history
Received:
August 03 2020
Revision Received:
September 14 2020
Accepted:
September 16 2020
Citation
Samuel Lewin, Stuart Hunt, Daniel W. Lambert; Extracellular vesicles and the extracellular matrix: a new paradigm or old news?. Biochem Soc Trans 30 October 2020; 48 (5): 2335–2345. doi: https://doi.org/10.1042/BST20200717
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