LncRNAs (long non-coding RNAs) are pervasively transcribed in the human genome and also extensively involved in a variety of essential biological processes and human diseases. The comprehensive annotation of human lncRNAs is of great significance in navigating the functional landscape of the human genome and deepening the understanding of the multi-featured RNA world. However, the unique characteristics of lncRNAs as well as their enormous quantity have complicated and challenged the annotation of lncRNAs. Advances in high-throughput sequencing technologies give rise to a large volume of omics data that are generated at an unprecedented rate and scale, providing possibilities in the identification, characterization and functional annotation of lncRNAs. Here, we review the recent important discoveries of human lncRNAs through analysis of various omics data and summarize specialized lncRNA database resources. Moreover, we highlight the multi-omics integrative analysis as a powerful strategy to efficiently discover and characterize the functional lncRNAs and elucidate their potential molecular mechanisms.
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Cover Image
Cover Image
The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. These codes cannot be readily discovered and understood without the use of computational modelling and algorithms. In this issue (see pages 1519–1528), Bahiri-Elitzur and Tuller summarize and discuss the different approaches that have been employed in the field in recent years. This cover artwork has been created by Hagar Messer and was provided by Tamir Tuller.
Multi-omics annotation of human long non-coding RNAs
Qianpeng Li, Zhao Li, Changrui Feng, Shuai Jiang, Zhang Zhang, Lina Ma; Multi-omics annotation of human long non-coding RNAs. Biochem Soc Trans 28 August 2020; 48 (4): 1545–1556. doi: https://doi.org/10.1042/BST20191063
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