Glycosylation is a major form of enzymatic modification of organic molecules responsible for multiple biological processes in an organism. The biosynthesis of glycans is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying enzymes that collectively assemble and process monosaccharide moieties into a diverse array of structures. Many studies have provided insight into various pathways of glycosylation at the ocular surface, such as those related to the biosynthesis of mucin-type O-glycans and N-glycans on proteins, but many others still remain largely unknown. This review provides an overview of the different classes of glycans described at the ocular surface focusing on their biosynthetic pathways and biological relevance. A precise understanding of these pathways under physiological and pathological conditions could help identify biomarkers and novel targets for therapeutic intervention.
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April 2018
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A 3D rendering of a Ubiquitin protein molecule. In this issue of Biochemical Society Transactions, Ovaa and Vertegaal discuss the role of ubiquitination and SUMO proteins in conjugation and deconjugation machineries; for details, see pages 423–436.
Review Article|
March 09 2018
Glycosylation pathways at the ocular surface
Maria C. Rodriguez Benavente;
Maria C. Rodriguez Benavente
1Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, U.S.A.
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Pablo Argüeso
1Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, U.S.A.
Correspondence: Pablo Argüeso (pablo_argueso@meei.harvard.edu)
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Publisher: Portland Press Ltd
Received:
January 03 2018
Revision Received:
January 23 2018
Accepted:
January 30 2018
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Biochem Soc Trans (2018) 46 (2): 343–350.
Article history
Received:
January 03 2018
Revision Received:
January 23 2018
Accepted:
January 30 2018
Citation
Maria C. Rodriguez Benavente, Pablo Argüeso; Glycosylation pathways at the ocular surface. Biochem Soc Trans 17 April 2018; 46 (2): 343–350. doi: https://doi.org/10.1042/BST20170408
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