The platelet is considered as an accessible and valuable tool to study mitochondrial function, owing to its greater content of fully functional mitochondria compared with other metabolically active organelles. Different lines of studies have demonstrated that mitochondria in platelets have function far more than thrombogenesis regulation, and beyond hemostasis, platelet mitochondrial dysfunction has also been used for studying mitochondrial-related diseases. In this review, the interplay between platelet mitochondrial dysfunction and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis and neurodegenerative disorders. Alongside this, we have also articulated our perspectives on the development of potential biomarkers of platelet mitochondrial dysfunction in mitochondrial-related diseases.
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Cover Image
Cover Image
Cryo-electron microscopy density map of a Cowpea Mosaic virus (CPMV) empty virus-like particle (eVLP) at 2.7 Å resolution (EMD-3952). The large (L) subunit is displayed in green and the small (S) subunit in blue. Five S subunits interact to form pronounced turrets at the 5-fold axis. Here we show a view down a two-fold axis. The eVLP was produced by transient co-expression in plants of the precursor of the L and S subunits (VP60) and the virus-encoded protease (24K) required for its processing. For further details, please see article by Lomonossoff et al, pages 1263–1269
Platelet mitochondrial dysfunction and the correlation with human diseases
Li Wang, Qiang Wu, Zhijia Fan, Rufeng Xie, Zhicheng Wang, Yuan Lu; Platelet mitochondrial dysfunction and the correlation with human diseases. Biochem Soc Trans 15 December 2017; 45 (6): 1213–1223. doi: https://doi.org/10.1042/BST20170291
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