Termed ‘master gene regulators’ long ncRNAs (lncRNAs) have emerged as the true vanguard of the ‘noncoding revolution’. Functioning at a molecular level, in most if not all cellular processes, lncRNAs exert their effects systemically. Thus, it is not surprising that lncRNAs have emerged as important players in human pathophysiology. As our body's first line of defense upon infection or injury, inflammation has been implicated in the etiology of several human diseases. At the center of the acute inflammatory response, as well as several pathologies, is the pleiotropic transcription factor NF-κβ. In this review, we attempt to capture a summary of lncRNAs directly involved in regulating innate immunity at various arms of the NF-κβ pathway that have also been validated in human disease. We also highlight the fundamental concepts required as lncRNAs enter a new era of diagnostic and therapeutic significance.
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August 2017
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Activating and inhibitory long non-coding RNAs of the NF-κβ canonical pathway. In this issue, Magagula et al. explore the lncRNAs that are directly involved in regulating innate immunity at various branches of the NF-κβ pathway, and also consider their potential diagnostic and therapeutic significance. For further details, see pages 953–962
Review Article|
July 07 2017
Lnc-ing inflammation to disease
Loretta Magagula;
1Division of Chemical Systems & Synthetic Biology, Institute for Infectious Disease & Molecular Medicine (IDM), Faculty of Health Sciences, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7925, South Africa
Correspondence: Loretta Magagula (loretta@mhlangalab.org) or Musa Mhlanga (musa@mhlangalab.org)
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Maria Gagliardi;
Maria Gagliardi
1Division of Chemical Systems & Synthetic Biology, Institute for Infectious Disease & Molecular Medicine (IDM), Faculty of Health Sciences, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7925, South Africa
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Jerolen Naidoo;
Jerolen Naidoo
2Gene Expression and Biophysics Group, CSIR Synthetic Biology ERA, Pretoria, South Africa
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Musa Mhlanga
1Division of Chemical Systems & Synthetic Biology, Institute for Infectious Disease & Molecular Medicine (IDM), Faculty of Health Sciences, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7925, South Africa
3Gene Expression and Biophysics Unit, Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal
Correspondence: Loretta Magagula (loretta@mhlangalab.org) or Musa Mhlanga (musa@mhlangalab.org)
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Publisher: Portland Press Ltd
Received:
March 17 2017
Revision Received:
May 26 2017
Accepted:
June 12 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (4): 953–962.
Article history
Received:
March 17 2017
Revision Received:
May 26 2017
Accepted:
June 12 2017
Citation
Loretta Magagula, Maria Gagliardi, Jerolen Naidoo, Musa Mhlanga; Lnc-ing inflammation to disease. Biochem Soc Trans 15 August 2017; 45 (4): 953–962. doi: https://doi.org/10.1042/BST20160377
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