Genomic analysis has found that the transcriptome in both humans and Drosophila melanogaster features large numbers of long non-coding RNA transcripts (lncRNAs). This recently discovered class of RNAs regulates gene expression in diverse ways and has been involved in a large variety of important biological functions. Importantly, an increasing number of lncRNAs have also been associated with a range of human diseases, including cancer. Comparative analyses of their functions among these organisms suggest that some of their modes of action appear to be conserved. This highlights the importance of model organisms such as Drosophila, which shares many gene regulatory networks with humans, in understanding lncRNA function and its possible impact in human health. This review discusses some known functions and mechanisms of action of lncRNAs and their implication in human diseases, together with their functional conservation and relevance in Drosophila development.
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August 2017
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Activating and inhibitory long non-coding RNAs of the NF-κβ canonical pathway. In this issue, Magagula et al. explore the lncRNAs that are directly involved in regulating innate immunity at various branches of the NF-κβ pathway, and also consider their potential diagnostic and therapeutic significance. For further details, see pages 953–962
Review Article|
July 03 2017
Functions of long non-coding RNAs in human disease and their conservation in Drosophila development
Oliver M. Rogoyski;
Oliver M. Rogoyski
1Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, U.K.
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Jose Ignacio Pueyo;
Jose Ignacio Pueyo
1Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, U.K.
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Juan Pablo Couso;
Juan Pablo Couso
1Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, U.K.
2Centro Andaluz de Biología de Desarrollo, CSIC—Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, Sevilla 41013, Spain
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Sarah F. Newbury
1Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, U.K.
Correspondence: Sarah F. Newbury (s.newbury@bsms.ac.uk)
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Publisher: Portland Press Ltd
Received:
March 17 2017
Revision Received:
May 18 2017
Accepted:
May 31 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (4): 895–904.
Article history
Received:
March 17 2017
Revision Received:
May 18 2017
Accepted:
May 31 2017
Citation
Oliver M. Rogoyski, Jose Ignacio Pueyo, Juan Pablo Couso, Sarah F. Newbury; Functions of long non-coding RNAs in human disease and their conservation in Drosophila development. Biochem Soc Trans 15 August 2017; 45 (4): 895–904. doi: https://doi.org/10.1042/BST20160428
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