The endogenous circadian clock is a key regulator of daily metabolic processes. On the other hand, circadian clocks in a broad range of tissues can be tuned by extrinsic and intrinsic metabolic cues. The bidirectional interaction between circadian clocks and metabolism involves both transcriptional and post-translational mechanisms. Nuclear receptors exemplify the transcriptional programs that couple molecular clocks to metabolism. The post-translational modifications of the core clock machinery are known to play a key role in metabolic entrainment of circadian clocks. O-linked N-acetylglucosamine modification (O-GlcNAcylation) of intracellular proteins is a key mediator of metabolic response to nutrient availability. This review highlights our current understanding of the role of protein O-GlcNAcylation in mediating metabolic input and output of the circadian clock.
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Activating and inhibitory long non-coding RNAs of the NF-κβ canonical pathway. In this issue, Magagula et al. explore the lncRNAs that are directly involved in regulating innate immunity at various branches of the NF-κβ pathway, and also consider their potential diagnostic and therapeutic significance. For further details, see pages 953–962
Review Article|
July 03 2017
The sweet tooth of the circadian clock
Minnie Fu;
Minnie Fu
1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, U.S.A.
2Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, U.S.A.
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Xiaoyong Yang
1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, U.S.A.
2Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, U.S.A.
3Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, U.S.A.
Correspondence: Xiaoyong Yang (xiaoyong.yang@yale.edu)
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Publisher: Portland Press Ltd
Received:
February 23 2017
Revision Received:
May 04 2017
Accepted:
May 16 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (4): 871–884.
Article history
Received:
February 23 2017
Revision Received:
May 04 2017
Accepted:
May 16 2017
Citation
Minnie Fu, Xiaoyong Yang; The sweet tooth of the circadian clock. Biochem Soc Trans 15 August 2017; 45 (4): 871–884. doi: https://doi.org/10.1042/BST20160183
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