T cells release ample amounts of cytokines during infection. This property is critical to prevent pathogen spreading and persistence. Nevertheless, whereas rapid and ample cytokine production supports the clearance of pathogens, the production must be restricted in time and location to prevent detrimental effects of chronic inflammation and immunopathology. Transcriptional and post-transcriptional processes determine the levels of cytokine production. How these regulatory mechanisms are interconnected, and how they regulate the magnitude of protein production in primary T cells is to date not well studied. Here, we highlight recent advances in the field that boost our understanding of the regulatory processes of cytokine production of T cells, with a focus on transcription, mRNA stability, localization and translation.
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April 2017
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Cover Image
Cover Image
This artistic rendition shows an Atomic Force Microscopy tip probing the mechanics of an individual virus particle. The colour scale of the particle indicates the deformation and stress of the viral shell obtained with Finite Element Analysis. The applied force is monitored by focusing a laser beam at the end of the microcantilever. For more information please see study by Moreno-Madrid et al. in this issue, pages 499–511. Image provided by Pedro De Pablo.
Review Article|
April 13 2017
Visualizing the life of mRNA in T cells
Benoit P. Nicolet;
Benoit P. Nicolet
1Department of Hematopoiesis, Sanquin Research, AMC Landsteiner Laboratory, Amsterdam, The Netherlands
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Fiamma Salerno;
Fiamma Salerno
1Department of Hematopoiesis, Sanquin Research, AMC Landsteiner Laboratory, Amsterdam, The Netherlands
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Monika C. Wolkers
1Department of Hematopoiesis, Sanquin Research, AMC Landsteiner Laboratory, Amsterdam, The Netherlands
Correspondence: Monika Wolkers (m.wolkers@sanquin.nl)
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Publisher: Portland Press Ltd
Received:
January 05 2017
Revision Received:
February 23 2017
Accepted:
February 27 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (2): 563–570.
Article history
Received:
January 05 2017
Revision Received:
February 23 2017
Accepted:
February 27 2017
Citation
Benoit P. Nicolet, Fiamma Salerno, Monika C. Wolkers; Visualizing the life of mRNA in T cells. Biochem Soc Trans 15 April 2017; 45 (2): 563–570. doi: https://doi.org/10.1042/BST20170003
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