Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
Keywords:
bone morphogenetic protein,
collagen,
ECM,
hyaluronic acid,
mechanosignaling,
proteoglycan
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
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