The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk degradation by macroautophagy is relatively well established, the selective autophagic degradation of mitochondria has only recently begun to receive significant attention. In this mini-review, we introduce mitophagy as a form of mitochondrial quality control and proceed to provide specific examples from yeast and mammalian systems. We then discuss the relationship of mitophagy to mitochondrial stress, and provide a broad mechanistic overview of the process with an emphasis on evolutionarily conserved pathways.
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April 2016
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Cover Image
Endoplasmic reticulumendosome contact sites. This pseudo-colored electron microscopy image shows the formation of inter-organelle membrane contact sites between late endosomes (magenta) and the endoplasmic reticulum (ER; green). This tethering results from the interaction between two ER-anchored proteins (VAP-A and VAP-B) and the late endosomeanchored protein STARD3NL. Mitochondria: brown; nucleus: blue. For further details see pp. 493-498. Image kindly provided by Fabien Alpy. - PDF Icon PDF LinkTable of Contents
Review Article|
April 11 2016
Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae
Hagai Abeliovich;
Hagai Abeliovich
*Department of Biochemistry and Food Science, Hebrew University of Jerusalem, Rehovot 76100, Israel
†Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Albertstr. 19, 79104 Freiburg, Germany
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Jörn Dengjel
Jörn Dengjel
‡Department of Dermatology, Medical Center, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Albertstr. 19, 79104 Freiburg, Germany
§ZBSA Center for Biological Systems Analysis, University of Freiburg, Habsburgerstr. 49, 79104 Freiburg, Germany
║Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland
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Publisher: Portland Press Ltd
Received:
January 25 2016
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 Authors; published by Portland Press Limited
2016
Biochem Soc Trans (2016) 44 (2): 541–545.
Article history
Received:
January 25 2016
Citation
Hagai Abeliovich, Jörn Dengjel; Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae. Biochem Soc Trans 15 April 2016; 44 (2): 541–545. doi: https://doi.org/10.1042/BST20150278
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