Phosphoinositides are a family of phospholipid messenger molecules that control various aspects of cell biology in part by interacting with and regulating downstream protein partners. Importantly, phosphoinositides are present in the nucleus. They form part of the nuclear envelope and are present within the nucleus in nuclear speckles, intra nuclear chromatin domains, the nuclear matrix and in chromatin. What their exact role is within these compartments is not completely clear, but the identification of nuclear specific proteins that contain phosphoinositide interaction domains suggest that they are important regulators of DNA topology, chromatin conformation and RNA maturation and export. The plant homeo domain (PHD) finger is a phosphoinositide binding motif that is largely present in nuclear proteins that regulate chromatin conformation. In the present study I outline how changes in the levels of the nuclear phosphoinositide PtdIns5P impact on muscle cell differentiation through the PHD finger of TAF3 (TAF, TATA box binding protein (TBP)-associated factor), which is a core component of a number of different basal transcription complexes.
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February 2016
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Scanning electron micrograph of a cell from the endosperm of a barley grain. The cell is tightly packed with large, disk-shaped (A-type) and much smaller, almost spherical (B-type) starch granules. The smooth areas in this image are the surface of the cell walls of neighbouring endosperm cells. For further details see pp. 157-163. Image kindly provided by Elaine Barclay and Vasilios Andriotis (John Innes Centre, Norwich). - PDF Icon PDF LinkTable of Contents
Review Article|
February 09 2016
Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle
Nullin Divecha
Nullin Divecha
1
*Centre for biological sciences, Building 84, Highfield Campus, University of Southampton, Southampton SO17 1BJ, U.K.
†INGM (Istituto Nazionale Genetica Molecolare), Padiglione ROMEO INVERNIZZI ed ENRICA PESSINA, Via Francesco Sforza, 35–20122 Milano, Italy
1email n.divecha@soton.ac.uk.
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Publisher: Portland Press Ltd
Received:
November 27 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 Authors; published by Portland Press Limited
2016
Biochem Soc Trans (2016) 44 (1): 299–306.
Article history
Received:
November 27 2015
Citation
Nullin Divecha; Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle. Biochem Soc Trans 15 February 2016; 44 (1): 299–306. doi: https://doi.org/10.1042/BST20150238
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