Marine diatoms have potential as a biotechnological production platform, especially for lipid-derived products, including biofuels. Here we introduce some features of diatom metabolism, particularly with respect to photosynthesis, photorespiration and lipid synthesis and their differences relative to other photosynthetic eukaryotes. Since structural metabolic modelling of other photosynthetic organisms has been shown to be capable of representing their metabolic capabilities realistically, we briefly review the main approaches to this type of modelling. We then propose that genome-scale modelling of the diatom Phaeodactylum tricornutum, in response to varying light intensity, could uncover the novel aspects of the metabolic potential of this organism.
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December 2015
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Review Article|
November 27 2015
Modelling metabolism of the diatom Phaeodactylum tricornutum
Dipali Singh;
Dipali Singh
*Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717, U.S.A.
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Ross Carlson;
Ross Carlson
†Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, U.K.
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David Fell;
David Fell
*Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717, U.S.A.
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Mark Poolman
Mark Poolman
1
*Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717, U.S.A.
1To whom correspondence should be addressed (emailmgpoolman@brookes.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 24 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (6): 1182–1186.
Article history
Received:
July 24 2015
Citation
Dipali Singh, Ross Carlson, David Fell, Mark Poolman; Modelling metabolism of the diatom Phaeodactylum tricornutum. Biochem Soc Trans 1 December 2015; 43 (6): 1182–1186. doi: https://doi.org/10.1042/BST20150152
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