In recent years, bio-based chemicals have gained interest as a renewable alternative to petrochemicals. However, there is a significant need to assess the technological, biological, economic and environmental feasibility of bio-based chemicals, particularly during the early research phase. Recently, the Multi-scale framework for Sustainable Industrial Chemicals (MuSIC) was introduced to address this issue by integrating modelling approaches at different scales ranging from cellular to ecological scales. This framework can be further extended by incorporating modelling of the petrochemical value chain and the de novo prediction of metabolic pathways connecting existing host metabolism to desirable chemical products. This multi-scale, multi-disciplinary framework for quantitative assessment of bio-based chemicals will play a vital role in supporting engineering, strategy and policy decisions as we progress towards a sustainable chemical industry.
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December 2015
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Review Article|
November 27 2015
A multi-scale, multi-disciplinary approach for assessing the technological, economic and environmental performance of bio-based chemicals
Markus Herrgård;
Markus Herrgård
*Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark
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Sumesh Sukumara;
Sumesh Sukumara
*Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark
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Miguel Campodonico;
Miguel Campodonico
*Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark
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Kai Zhuang
Kai Zhuang
1
*Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark
1To whom correspondence should be addressed (emailkazh@biosustain.dtu.dk).
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Publisher: Portland Press Ltd
Received:
June 23 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (6): 1151–1156.
Article history
Received:
June 23 2015
Citation
Markus Herrgård, Sumesh Sukumara, Miguel Campodonico, Kai Zhuang; A multi-scale, multi-disciplinary approach for assessing the technological, economic and environmental performance of bio-based chemicals. Biochem Soc Trans 1 December 2015; 43 (6): 1151–1156. doi: https://doi.org/10.1042/BST20150144
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