The ABC (ATP-binding cassette) transporter family in higher plants is highly expanded compared with those of mammalians. Moreover, some members of the plant ABC subfamily B (ABCB) display very high substrate specificity compared with their mammalian counterparts that are often associated with multi-drug resistance phenomena. In this review, we highlight prominent functions of plant and mammalian ABC transporters and summarize our knowledge on their post-transcriptional regulation with a focus on protein phosphorylation. A deeper comparison of regulatory events of human cystic fibrosis transmembrane conductance regulator (CFTR) and ABCB1 from the model plant Arabidopsis reveals a surprisingly high degree of similarity. Both physically interact with orthologues of the FK506-binding proteins that chaperon both transporters to the plasma membrane in an action that seems to involve heat shock protein (Hsp)90. Further, both transporters are phosphorylated at regulatory domains that connect both nt-binding folds. Taken together, it appears that ABC transporters exhibit an evolutionary conserved but complex regulation by protein phosphorylation, which apparently is, at least in some cases, tightly connected with protein–protein interactions (PPI).
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October 2015
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Review Article|
October 09 2015
Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems
Bibek Aryal;
Bibek Aryal
*Department of Biology–Plant Biology, University of Fribourg, Rue Albert Gockel 3, PER04, CH-1700 Fribourg, Switzerland
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Christophe Laurent;
Christophe Laurent
*Department of Biology–Plant Biology, University of Fribourg, Rue Albert Gockel 3, PER04, CH-1700 Fribourg, Switzerland
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Markus Geisler
Markus Geisler
1
*Department of Biology–Plant Biology, University of Fribourg, Rue Albert Gockel 3, PER04, CH-1700 Fribourg, Switzerland
1To whom correspondence should be addressed (emailmarkus.geisler@unifr.ch).
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Publisher: Portland Press Ltd
Received:
May 27 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 966–974.
Article history
Received:
May 27 2015
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A correction has been published:
Correction: Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems
Citation
Bibek Aryal, Christophe Laurent, Markus Geisler; Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems. Biochem Soc Trans 1 October 2015; 43 (5): 966–974. doi: https://doi.org/10.1042/BST20150128
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