Tribbles family of pseudokinase proteins are known to mediate the degradation of target proteins in Drosophila and mammalian systems. The main protein proteolysis pathway in eukaryotic cells is the ubiquitin proteasome system (UPS). The tribbles homolog 2 (TRIB2) mammalian family member has been well characterized for its role in murine and human leukaemia, lung and liver cancer. One of the most characterized substrates for TRIB2-mediated degradation is the myeloid transcription factor CCAAT enhancer binding protein α (C/EBPα). However, across a number of cancers, the molecular interactions that take place between TRIB2 and factors involved in the UPS are varied and have differential downstream effects. This review summarizes our current knowledge of these interactions and how this information is important for our understanding of TRIB2 in cancer.
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October 2015
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Review Article|
October 09 2015
TRIB2 and the ubiquitin proteasome system in cancer
Mara Salomè;
Mara Salomè
*Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, G12 0ZD, Scotland
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Joana Campos;
Joana Campos
*Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, G12 0ZD, Scotland
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Karen Keeshan
Karen Keeshan
1
*Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, G12 0ZD, Scotland
1To whom correspondence should be addressed (emailKaren.keeshan@glasgow.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 06 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 1089–1094.
Article history
Received:
May 06 2015
Citation
Mara Salomè, Joana Campos, Karen Keeshan; TRIB2 and the ubiquitin proteasome system in cancer. Biochem Soc Trans 1 October 2015; 43 (5): 1089–1094. doi: https://doi.org/10.1042/BST20150103
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