Carbamate bonds occur following the nucleophilic attack of CO2 on to an amine. In proteins, this can occur at lysine side chains or at the N-terminus. For CO2 binding to occur an amine must be present in the NH2 form and consequently carbamates represent a site-specific post-translational modification, occurring only in environments of reduced hydration. Due to the specific nature of these interactions, coupled with the inability of these bonds to survive protein preparation methods, carbamate reactions appear rare. However, more biologically important examples continue to emerge that use carbamates as key parts of their mechanisms. In this review, we discuss specific examples of carbamate bond formation and their biological consequences with an aim to highlight this important, and often forgotten, biochemical group.
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June 2015
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Conference Article|
June 01 2015
CO2 carbamylation of proteins as a mechanism in physiology
Louise Meigh
Louise Meigh
1
*School of Life Sciences, University of Warwick, Coventry, CV4 7AL, U.K.
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Publisher: Portland Press Ltd
Received:
January 27 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (3): 460–464.
Article history
Received:
January 27 2015
Citation
Louise Meigh; CO2 carbamylation of proteins as a mechanism in physiology. Biochem Soc Trans 1 June 2015; 43 (3): 460–464. doi: https://doi.org/10.1042/BST20150026
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