The ryanodine receptor/Ca2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation–contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses on channel regulation through structural intra- and inter-subunit interactions and their implications in ryanodine receptor pathophysiology.

Keywords:
Ca2+ release channel, excitation–contraction coupling, inter-domain interactions, oligomerization, pathophysiology, ryanodine receptor
© The Authors Journal compilation © 2015 Biochemical Society
2015
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