There is increasing evidence that a deficiency in vitamin D contributes to many human diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular disease. The ability of vitamin D to maintain healthy cells seems to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways. This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways. A decline in vitamin D levels will lead to an erosion of this signalling stability and may account for why so many of the major diseases in man, which have been linked to vitamin D deficiency, are associated with a dysregulation in both ROS and Ca2+ signalling.
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June 2015
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Conference Article|
June 01 2015
Vitamin D: a custodian of cell signalling stability in health and disease
Michael J. Berridge
Michael J. Berridge
1
*The Babraham Institute, Babraham, Cambridge, CB22 3AT, U.K.
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Publisher: Portland Press Ltd
Received:
October 21 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (3): 349–358.
Article history
Received:
October 21 2014
Citation
Michael J. Berridge; Vitamin D: a custodian of cell signalling stability in health and disease. Biochem Soc Trans 1 June 2015; 43 (3): 349–358. doi: https://doi.org/10.1042/BST20140279
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