There has recently been a huge increase in interest in the formation of stable G-quadruplex structures in mRNAs and their functional significance. In neurons, local translation of mRNA is essential for normal neuronal behaviour. It has been discovered that local translation of specific mRNAs encoding some of the best known synaptic proteins is dependent on the presence of a G-quadruplex. The recognition of G-quadruplexes in mRNAs, their transport as repressed complexes and the control of their translation at their subcellular destinations involves a diversity of proteins, including those associated with disease pathologies. This is an exciting field, with rapid improvements to our knowledge and understanding. Here, we discuss some of the recent work on how G-quadruplexes mediate local translation in neurons.
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June 2015
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Conference Article|
June 01 2015
G-quadruplexes mediate local translation in neurons
James P.R. Schofield;
James P.R. Schofield
1
*Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, U.K.
1To whom correspondence should be addressed (emailJ.P.R.Schofield@soton.ac.uk).
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Joanne L. Cowan;
Joanne L. Cowan
*Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, U.K.
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Mark J. Coldwell
Mark J. Coldwell
*Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, U.K.
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Publisher: Portland Press Ltd
Received:
February 19 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (3): 338–342.
Article history
Received:
February 19 2015
Citation
James P.R. Schofield, Joanne L. Cowan, Mark J. Coldwell; G-quadruplexes mediate local translation in neurons. Biochem Soc Trans 1 June 2015; 43 (3): 338–342. doi: https://doi.org/10.1042/BST20150053
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