Mitochondrial dysfunction is a hallmark of both idiopathic and familial Parkinson's disease (PD). Mutations in the PARK2 and PARK6 genes, coding for the cytosolic E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1], lead to clinically similar early-onset Parkinsonian syndromes. PINK1 and Parkin cooperate within a conserved pathway to preserve mitochondrial quality through the regulation of a variety of processes, including mitochondrial dynamics, transport, bioenergetics, biogenesis and turnover. The molecular mechanisms behind the orchestration of this plethora of functions remain poorly understood. In the present review, we emphasize the functional overlap between the PINK1–Parkin pathway and the endoplasmic reticulum (ER)-mitochondria interface, a subcellular compartment critically involved in neurodegeneration. We discuss how this compartment may constitute a hub for the spatiotemporal organization of the activities of the PINK1–Parkin pathway.
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April 2015
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Conference Article|
April 07 2015
The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1–Parkin pathway?
Zoi Erpapazoglou;
Zoi Erpapazoglou
*Institut national de la santé et de la recherche médicale, Inserm, U1127, F-75013, Paris, France
†Centre national de la recherche scientifique, CNRS, UMR 7225, F-75013, Paris, France
‡Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France
§Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France
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Olga Corti
Olga Corti
1
*Institut national de la santé et de la recherche médicale, Inserm, U1127, F-75013, Paris, France
†Centre national de la recherche scientifique, CNRS, UMR 7225, F-75013, Paris, France
‡Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France
§Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France
1To whom correspondence should be addressed (emailolga.corti@upmc.fr).
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Publisher: Portland Press Ltd
Received:
January 12 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (2): 297–301.
Article history
Received:
January 12 2015
Citation
Zoi Erpapazoglou, Olga Corti; The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1–Parkin pathway?. Biochem Soc Trans 1 April 2015; 43 (2): 297–301. doi: https://doi.org/10.1042/BST20150008
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