Defects of mitochondrial functions have been implicated in many different human diseases, in particular neurodegenerative diseases. The kinase PINK1 [phosphatase and tensin homologue (PTEN)-induced kinase 1] has been identified as a crucial player in a specific damage signalling pathway, eliminating defective mitochondria by an autophagic process. Mutations in PINK1 have been shown to cause familial cases of Parkinson's disease. In this review, we summarize the biochemical mechanisms that underlie the association of PINK1 with mitochondria under normal and pathological conditions. This unconventional mitochondrial localization pathway is discussed in the context of the role of PINK1 as a sensor of mitochondrial damage and a causative factor in Parkinson's disease.
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April 2015
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Conference Article|
April 07 2015
Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling
Cornelia Rüb;
Cornelia Rüb
*Institut für Biochemie und Molekularbiologie (IBMB), Universität Bonn, Nussallee 11, D-53115 Bonn, Germany
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Nadja Schröder;
Nadja Schröder
*Institut für Biochemie und Molekularbiologie (IBMB), Universität Bonn, Nussallee 11, D-53115 Bonn, Germany
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Wolfgang Voos
Wolfgang Voos
1
*Institut für Biochemie und Molekularbiologie (IBMB), Universität Bonn, Nussallee 11, D-53115 Bonn, Germany
1To whom correspondence should be addressed (emailwolfgang.voos@uni-bonn.de).
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Publisher: Portland Press Ltd
Received:
January 08 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (2): 287–291.
Article history
Received:
January 08 2015
Citation
Cornelia Rüb, Nadja Schröder, Wolfgang Voos; Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling. Biochem Soc Trans 1 April 2015; 43 (2): 287–291. doi: https://doi.org/10.1042/BST20150005
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