Moonlighting proteins perform multiple independent cellular functions within one polypeptide chain. Moonlighting proteins switch functions depending on various factors including the cell-type in which they are expressed, cellular location, oligomerization status and the binding of different ligands at different sites. Although an increasing number of moonlighting proteins have been experimentally identified in recent years, the quantity of known moonlighting proteins is insufficient to elucidate their overall landscape. Moreover, most moonlighting proteins have been identified as a serendipitous discovery. Hence, characterization of moonlighting proteins using bioinformatics approaches can have a significant impact on the overall understanding of protein function. In this work, we provide a short review of existing computational approaches for illuminating the functional diversity of moonlighting proteins.
Skip Nav Destination
Article navigation
December 2014
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 17 2014
Computational characterization of moonlighting proteins
Ishita K. Khan;
Ishita K. Khan
*Department of Computer Science, Purdue University, West Lafayette, IN 47907, U.S.A.
Search for other works by this author on:
Daisuke Kihara
Daisuke Kihara
1
*Department of Computer Science, Purdue University, West Lafayette, IN 47907, U.S.A.
†Department of Biological Science, Purdue University, West Lafayette, IN 47907, U.S.A.
1To whom correspondence should be addressed (emaildkihara@purdue.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 04 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1780–1785.
Article history
Received:
August 04 2014
Citation
Ishita K. Khan, Daisuke Kihara; Computational characterization of moonlighting proteins. Biochem Soc Trans 1 December 2014; 42 (6): 1780–1785. doi: https://doi.org/10.1042/BST20140214
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.