Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
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December 2014
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Conference Article|
November 17 2014
Extracellular cell stress proteins as biomarkers of human disease
A. Graham Pockley;
A. Graham Pockley
1
*The John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham NG11 8NS, U.K.
1To whom correspondence should be addressed (emailgraham.pockley@ntu.ac.uk).
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Brian Henderson;
Brian Henderson
†Department of Microbial Diseases, UCL-Eastman Dental Institute, University College London, London WC1X 8LD, U.K.
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Gabriele Multhoff
Gabriele Multhoff
‡Department of Radiation Oncology, Technische Universität München, Klinikum rechts der Isar, D-81675 Munich, Germany
§Helmholtz Center Munich, German Research Center for Environmental Health, CCG–“Innate Immunity in Tumor Biology”, D-81675 Munich, Germany
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Publisher: Portland Press Ltd
Received:
August 11 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1744–1751.
Article history
Received:
August 11 2014
Citation
A. Graham Pockley, Brian Henderson, Gabriele Multhoff; Extracellular cell stress proteins as biomarkers of human disease. Biochem Soc Trans 1 December 2014; 42 (6): 1744–1751. doi: https://doi.org/10.1042/BST20140205
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