Therapeutic angiogenesis is an attractive strategy to treat patients suffering from ischaemic conditions and vascular endothelial growth factor-A (VEGF) is the master regulator of blood vessel growth. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose localized in the microenvironment around each producing cell in vivo and on the balanced stimulation of platelet-derived growth factor-BB (PDGF-BB) signalling, responsible for pericyte recruitment. At the doses required to induce therapeutic benefit, VEGF causes new vascular growth essentially without sprouting, but rather through the alternative process of intussusception, or vascular splitting. In the present article, we briefly review the therapeutic implications of controlling VEGF dose on one hand and pericyte recruitment on the other, as well as the key features of intussusceptive angiogenesis and its regulation.
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December 2014
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Conference Article|
November 17 2014
Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis
Roberto Gianni-Barrera;
Roberto Gianni-Barrera
1
*Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland
†Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee, D-18057 Rostock, Germany
1Correspondence may be addressed to either of these authors (emailroberto.giannibarrera@usb.ch or andrea.banfi@usb.ch).
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Mariateresa Bartolomeo;
Mariateresa Bartolomeo
*Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland
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Brigitte Vollmar;
Brigitte Vollmar
†Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee, D-18057 Rostock, Germany
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Valentin Djonov;
Valentin Djonov
‡Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH-3000 Bern, Switzerland
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Andrea Banfi
Andrea Banfi
1
*Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland
1Correspondence may be addressed to either of these authors (emailroberto.giannibarrera@usb.ch or andrea.banfi@usb.ch).
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Publisher: Portland Press Ltd
Received:
September 05 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1637–1642.
Article history
Received:
September 05 2014
Citation
Roberto Gianni-Barrera, Mariateresa Bartolomeo, Brigitte Vollmar, Valentin Djonov, Andrea Banfi; Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis. Biochem Soc Trans 1 December 2014; 42 (6): 1637–1642. doi: https://doi.org/10.1042/BST20140234
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