The immunological synapse controls T-lymphocyte function by polarizing effector responses towards the antigen-presenting cell. In this review, I discuss the molecular pathways required for synapse assembly, focusing on the central roles played by lipid second-messenger signalling.

Keywords:
actin, cell polarity, microtubule, protein kinase C (PKC), signal transduction, T-cell
© The Authors Journal compilation © 2014 Biochemical Society
2014
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