Protein kinase C (PKC) is a family of ten serine/threonine kinases that have diverse roles in the signalling pathways regulating cellular proliferation, differentiation, apoptosis and immune responses. Elucidating roles for individual PKC isoforms in the immune responses of T-cells have long been a challenging prospect, because these cells are known to express nine of these isoforms. A variety of approaches including the use of knockout mice, overexpression of kinase-inactive mutants, cell-permeable peptides, pharmacological inhibitors and siRNAs have shown that PKCs regulate the production of inflammatory cytokines and the cytotoxic responses of various T-cell subsets. Central to the T-cell immune response is a requirement to migrate to various organs and tissues in search of pathogens and micro-organisms. T-cell migration is guided by specific sets of chemokines and integrin ligands that activate their cognate chemokine receptors and integrins on T-cells, resulting in remodelling of the cytoskeleton and the dynamic protrusive/contractile forces necessary for cell adhesion and motility. In the present article, we review the role of PKC in T-cell migration, with an emphasis on studies that have defined their roles in cytoskeletal remodelling, cell polarity and intracellular trafficking downstream of chemokine receptors and integrins.
Skip Nav Destination
Article navigation
December 2014
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 17 2014
Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration
Aideen Long;
Aideen Long
*Department of Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland
Search for other works by this author on:
Michael Freeley
Michael Freeley
1
*Department of Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland
1To whom correspondence should be addressed (emailfreeleym@tcd.ie).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 28 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1490–1497.
Article history
Received:
July 28 2014
Citation
Aideen Long, Michael Freeley; Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration. Biochem Soc Trans 1 December 2014; 42 (6): 1490–1497. doi: https://doi.org/10.1042/BST20140204
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.