Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability is, however, poorly understood. Lipophilic or amphiphilic compounds with a basic moiety will become protonated and trapped within lysosomes, and such lysosomotropic behaviour is also found in many pharmacological drugs. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future. The present review summarizes the current knowledge on the targeting and permeabilizing properties of lysosomotropic detergents from a cellular and physicochemical perspective.
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October 2014
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Conference Article|
September 18 2014
Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death
Ana M. Villamil Giraldo;
Ana M. Villamil Giraldo
*Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Pathology Clinic, County Council of Östergötland, S-58158 Linköping, Sweden
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Hanna Appelqvist;
Hanna Appelqvist
†Division of Chemistry, Department of Physics, Chemistry and Biology, Linköping University, S-58183 Linköping, Sweden
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Thomas Ederth;
Thomas Ederth
‡Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linköping University, S-58183 Linköping, Sweden
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Karin Öllinger
Karin Öllinger
1
*Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Pathology Clinic, County Council of Östergötland, S-58158 Linköping, Sweden
1To whom correspondence should be addressed (emailkarin.ollinger@liu.se).
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Publisher: Portland Press Ltd
Received:
May 21 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (5): 1460–1464.
Article history
Received:
May 21 2014
Citation
Ana M. Villamil Giraldo, Hanna Appelqvist, Thomas Ederth, Karin Öllinger; Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death. Biochem Soc Trans 1 October 2014; 42 (5): 1460–1464. doi: https://doi.org/10.1042/BST20140145
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