Macroautophagy (autophagy hereafter) is an evolutionarily highly conserved catabolic process activated by eukaryotes in order to counteract cellular starvation. Autophagy leads to bulk degradation of cytoplasmic content in the lysosomal compartment, thereby clearing the cytoplasm and generating nutrients and energy. Upon autophagy initiation, cytoplasmic material becomes sequestered in newly formed double-membrane vesicles termed ‘autophagosomes’ that subsequently acquire acidic hydrolases for content destruction. The de novo biogenesis of autophagosomes often occurs at the endoplasmic reticulum (ER) and, in many cases, in close proximity to lipid droplets (LDs), intracellular neutral lipid storage reservoirs. LDs are targets of autophagic destruction, but have recently also been shown to contribute to autophagosome formation. In fact, some autophagy-related (Atg) proteins, such as microtubule-associated protein light chain 3 (LC3), Atg2 and Atg14L, functionally contribute to both LD and autophagosome biogenesis. In the present paper, we discuss Atg proteins, including members of the human WD-repeat protein interacting with phosphoinositides (WIPI) family that co-localize prominently with LC3, Atg2 and Atg14L to conceivably integrate LD and autophagosome dynamics.
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October 2014
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Conference Article|
September 18 2014
WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics
Simon G. Pfisterer;
Simon G. Pfisterer
1
*Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
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Daniela Bakula;
Daniela Bakula
*Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
†International Max Planck Research School ‘From Molecules to Organisms’, Max Planck Institute for Developmental Biology and Eberhard Karls University Tübingen, Spemannstrasse 35–39, 72076 Tübingen, Germany
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Alice Cezanne;
Alice Cezanne
*Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
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Horst Robenek;
Horst Robenek
‡University Clinic Münster, Albert-Schweitzer-Campus 1, Domagstrasse 3, 48149 Münster, Germany
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Tassula Proikas-Cezanne
Tassula Proikas-Cezanne
2
*Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
†International Max Planck Research School ‘From Molecules to Organisms’, Max Planck Institute for Developmental Biology and Eberhard Karls University Tübingen, Spemannstrasse 35–39, 72076 Tübingen, Germany
2To whom correspondence should be addressed (emailtassula.proikas-cezanne@uni-tuebingen.de).
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Publisher: Portland Press Ltd
Received:
May 23 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (5): 1414–1417.
Article history
Received:
May 23 2014
Citation
Simon G. Pfisterer, Daniela Bakula, Alice Cezanne, Horst Robenek, Tassula Proikas-Cezanne; WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics. Biochem Soc Trans 1 October 2014; 42 (5): 1414–1417. doi: https://doi.org/10.1042/BST20140152
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