Atherothrombotic disease is a well-recognized complication of diabetes and is a major contributor to the high morbidity and mortality associated with diabetes. Although there is substantial evidence linking diabetes with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key steps in the atherothrombotic process. Endothelial cells are particularly susceptible to ROS-mediated dysfunction not only because of reduced cell viability and increased senescence, but also because one of the major endothelium-derived factors that help to protect against atherosclerosis, nitric oxide, is rapidly deactivated by superoxide radicals.
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August 2014
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Conference Article|
August 11 2014
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Andrew Shaw;
Andrew Shaw
*Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness IV2 3JH, U.K.
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Mary K. Doherty;
Mary K. Doherty
*Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness IV2 3JH, U.K.
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Nicola J. Mutch;
Nicola J. Mutch
†School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, U.K.
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Sandra M. MacRury;
Sandra M. MacRury
*Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness IV2 3JH, U.K.
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Ian L. Megson
Ian L. Megson
1
*Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness IV2 3JH, U.K.
1To whom correspondence should be addressed (emailian.megson@uhi.ac.uk).
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Publisher: Portland Press Ltd
Received:
April 30 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 928–933.
Article history
Received:
April 30 2014
Citation
Andrew Shaw, Mary K. Doherty, Nicola J. Mutch, Sandra M. MacRury, Ian L. Megson; Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?. Biochem Soc Trans 1 August 2014; 42 (4): 928–933. doi: https://doi.org/10.1042/BST20140113
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