A primary site of infection in mammals is the nostrils, representing the gate to the brain through olfactory and vomeronasal epithelia, eyes as a direct route to the brain via the optical nerve, and oral cavity representing the main route to the digestive tract. Similarly, pheromones, odorants and tastants enter animal bodies the same way. Therefore similar evolutionary forces might have shaped the evolution of systems for recognition of pathogens and chemical signals. This might have resulted in sharing various proteins among systems of recognition and filtering to decrease potential costs of evolving and utilizing unique biochemical pathways. This has been documented previously in, for example, multipurpose and widely distributed GPCRs (G-protein-coupled receptors). The aim of the present review is to explore potential functional overlaps or complementary functions of lipocalins in the system of perception of exogenous substances to reconstruct the evolutionary forces that might have shaped their synergistic functions.
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Conference Article|
August 11 2014
Complementary roles of mouse lipocalins in chemical communication and immunity
Romana Stopková;
Romana Stopková
*BIOCEV group, Department of Zoology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
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Barbora Dudková;
Barbora Dudková
*BIOCEV group, Department of Zoology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
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Petra Hájková;
Petra Hájková
*BIOCEV group, Department of Zoology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
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Pavel Stopka
Pavel Stopka
1
*BIOCEV group, Department of Zoology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
1To whom correspondence should be addressed (emailpstopka@natur.cuni.cz).
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Publisher: Portland Press Ltd
Received:
March 04 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 893–898.
Article history
Received:
March 04 2014
Citation
Romana Stopková, Barbora Dudková, Petra Hájková, Pavel Stopka; Complementary roles of mouse lipocalins in chemical communication and immunity. Biochem Soc Trans 1 August 2014; 42 (4): 893–898. doi: https://doi.org/10.1042/BST20140053
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