In female mice, exposure to male chemosignals results in early puberty onset characterized by advanced vaginal opening and higher uterine weight. Evidence suggests that the male chemosignals responsible for acceleration of female puberty are androgen-dependent, but not all of the compounds that contribute to puberty acceleration have been identified. The male chemosignals are primarily detected and processed by the vomeronasal system including the vomeronasal organ, the accessory olfactory bulb and the medial amygdala. By contrast, the mechanism by which this olfactory information is integrated in the hypothalamus is poorly understood. In this context, the recent identification of the neuropeptide kisspeptin as a gatekeeper of puberty onset may provide a good candidate neuropeptide system for the transmission of chemosensory information to the gonadotrope axis.
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August 2014
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Conference Article|
August 11 2014
Female puberty acceleration by male odour in mice: neural pathway and behavioural consequences
Mélanie Jouhanneau;
Mélanie Jouhanneau
*Physiologie de la Reproduction et des Comportements, UMR 0085 INRA, Centre Val-de-Loire, F-37380, Nouzilly, France
†CNRS UMR 7247, F-37380, Nouzilly, France
‡Université François Rabelais de Tours, F-37041 Tours, France
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Laura A. Szymanski;
Laura A. Szymanski
1
*Physiologie de la Reproduction et des Comportements, UMR 0085 INRA, Centre Val-de-Loire, F-37380, Nouzilly, France
†CNRS UMR 7247, F-37380, Nouzilly, France
‡Université François Rabelais de Tours, F-37041 Tours, France
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Matthieu Keller
Matthieu Keller
2
*Physiologie de la Reproduction et des Comportements, UMR 0085 INRA, Centre Val-de-Loire, F-37380, Nouzilly, France
†CNRS UMR 7247, F-37380, Nouzilly, France
‡Université François Rabelais de Tours, F-37041 Tours, France
2To whom correspondence should be addressed (emailmkeller@tours.inra.fr).
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Publisher: Portland Press Ltd
Received:
March 26 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 878–881.
Article history
Received:
March 26 2014
Citation
Mélanie Jouhanneau, Laura A. Szymanski, Matthieu Keller; Female puberty acceleration by male odour in mice: neural pathway and behavioural consequences. Biochem Soc Trans 1 August 2014; 42 (4): 878–881. doi: https://doi.org/10.1042/BST20140048
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