The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs that are co-transcriptionally processed, folded and, while still within the nucleolus, associate with most of the ribosomal proteins. The nucleolus is therefore often thought of as a factory for making ribosomal subunits, which are exported as inactive precursors to the cytoplasm where late maturation makes them capable of mRNA binding and translation initiation. However, recent studies have shown substantial evidence for the presence of functional, translation competent ribosomal subunits within the nucleus, particularly in the nucleolus. These observations raise the intriguing possibility that the nucleolus, as well as being a ribosome factory, is also an important nuclear protein-synthesis plant.
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Conference Article|
August 11 2014
Recent studies implicate the nucleolus as the major site of nuclear translation
Tina McLeod;
Tina McLeod
1
*University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, U.K.
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Akilu Abdullahi;
Akilu Abdullahi
1
*University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, U.K.
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Min Li;
Min Li
*University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, U.K.
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Saverio Brogna
Saverio Brogna
2
*University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, U.K.
2To whom correspondence should be addressed (emails.brogna@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
March 31 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1224–1228.
Article history
Received:
March 31 2014
Citation
Tina McLeod, Akilu Abdullahi, Min Li, Saverio Brogna; Recent studies implicate the nucleolus as the major site of nuclear translation. Biochem Soc Trans 1 August 2014; 42 (4): 1224–1228. doi: https://doi.org/10.1042/BST20140062
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