Air pollution has been estimated to be responsible for several millions of deaths worldwide per year, the majority of which have been attributed to cardiovascular causes. The particulate matter in air pollution has been shown impair vascular function, increase blood pressure, promote thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress repeatedly emerges as a potential mechanism in all of these detrimental cardiovascular actions. The present mini-review will use diesel exhaust as an example of a pollutant rich in combustion-derived nanoparticles, to describe the potential by which oxidative stress could drive the cardiovascular effects of air pollution.
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August 2014
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Conference Article|
August 11 2014
The role of oxidative stress in the cardiovascular actions of particulate air pollution
Mark R. Miller
Mark R. Miller
1
*University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, U.K.
1emailmark.miller@ed.ac.uk
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Publisher: Portland Press Ltd
Received:
April 04 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Article history
Received:
April 04 2014
Citation
Mark R. Miller; The role of oxidative stress in the cardiovascular actions of particulate air pollution. Biochem Soc Trans 1 August 2014; 42 (4): 1006–1011. doi: https://doi.org/10.1042/BST20140090
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