MLCP (myosin light chain phosphatase) regulates platelet function through its ability to control myosin IIa phosphorylation. Recent evidence suggests that MLCP is a de facto target for signalling events stimulated by cAMP. In the present mini-review, we discuss the mechanisms by which cAMP signalling maintains MLCP in an active state to control platelet contractile machinery.

Keywords:
cAMP, myosin light chain phosphatase (MLCP), platelet, protein kinase A (PKA), RhoA, Rho-associated kinase (ROCK)
© The Authors Journal compilation © 2014 Biochemical Society
2014
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