The fission yeast Schizosaccharomyces pombe has been successfully used as a model to gain fundamental knowledge in understanding how eukaryotic cells acquire copper during vegetative growth. These studies have revealed the existence of a heteromeric Ctr4–Ctr5 plasma membrane complex that mediates uptake of copper within the cells. Furthermore, additional studies have led to the identification of one of the first vacuolar copper transporters, Ctr6, as well as the copper-responsive Cuf1 transcription factor. Recent investigations have extended the use of S. pombe to elucidate new roles for copper metabolism in meiotic differentiation. For example, these studies have led to the discovery of Mfc1, which turned out to be the first example of a meiosis-specific copper transporter. Whereas copper-dependent transcriptional regulation of the Ctr family members is under the control of Cuf1 during mitosis or meiosis, meiosis-specific copper transporter Mfc1 is regulated by the recently discovered transactivator Mca1. It is foreseeable that identification of novel meiotic copper-related proteins will serve as stepping stones to unravel fundamental aspects of copper homoeostasis.
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December 2013
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Conference Article|
November 20 2013
Copper transport and regulation in Schizosaccharomyces pombe
Jude Beaudoin;
Jude Beaudoin
*Département de Biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, rue Jean Mignault, Sherbrooke, QC, Canada, J1E 4K8
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Seda Ekici;
Seda Ekici
†Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, U.S.A.
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Fevzi Daldal;
Fevzi Daldal
†Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, U.S.A.
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Samia Ait-Mohand;
Samia Ait-Mohand
‡Département de Médecine Nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, and Centre d’imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, Sherbrooke, QC, Canada, J1H 5N4
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Brigitte Guérin;
Brigitte Guérin
‡Département de Médecine Nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, and Centre d’imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, Sherbrooke, QC, Canada, J1H 5N4
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Simon Labbé
Simon Labbé
1
*Département de Biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, rue Jean Mignault, Sherbrooke, QC, Canada, J1E 4K8
1To whom correspondence should be addressed (emailSimon.Labbe@USherbrooke.ca).
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Publisher: Portland Press Ltd
Received:
May 29 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (6): 1679–1686.
Article history
Received:
May 29 2013
Citation
Jude Beaudoin, Seda Ekici, Fevzi Daldal, Samia Ait-Mohand, Brigitte Guérin, Simon Labbé; Copper transport and regulation in Schizosaccharomyces pombe. Biochem Soc Trans 1 December 2013; 41 (6): 1679–1686. doi: https://doi.org/10.1042/BST2013089
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