Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health and resilience to oxidative stress, particularly in the context of neurodegenerative disease, which is characterized by progressive dysfunction and loss of neurons specifically, and in which oxidative stress is considered a central aetiological contributor. Biological factors which may influence neuronal susceptibility to oxidative stress, in normal and neurodegenerative contexts, are reviewed in the present article, with a focus on properties intrinsic to the neuronal cell type and on properties related to neuronal reliance on surrounding astrocytes.
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December 2013
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Conference Article|
November 20 2013
Insight into a neuron's preferential susceptibility to oxidative stress
Karen F.S. Bell
Karen F.S. Bell
1
*Centre for Integrative Physiology, Hugh Robson Building, 10/15 George Square, University of Edinburgh, Edinburgh EH8 9XD, U.K.
1emailkaren.fs.bell@ed.ac.uk
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Publisher: Portland Press Ltd
Received:
October 11 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Article history
Received:
October 11 2013
Citation
Karen F.S. Bell; Insight into a neuron's preferential susceptibility to oxidative stress. Biochem Soc Trans 1 December 2013; 41 (6): 1541–1545. doi: https://doi.org/10.1042/BST20130245
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