The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms, are key in the fight against the proteotoxicity that is often associated with severe neurodegenerative diseases. However, in recent years, a new theme has emerged which suggests that components of protein quality-control pathways are often targets of the toxic effects of pathogenic proteins and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as ‘saviour’ and ‘victim’ in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic proteins in lysosomes.
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December 2013
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Conference Article|
November 20 2013
Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena
Jaime L. Schneider;
Jaime L. Schneider
*Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
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Ana Maria Cuervo
Ana Maria Cuervo
1
*Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
1To whom correspondence should be addressed (emailana-maria.cuervo@einstein.yu.edu).
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Publisher: Portland Press Ltd
Received:
July 02 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Article history
Received:
July 02 2013
Citation
Jaime L. Schneider, Ana Maria Cuervo; Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena. Biochem Soc Trans 1 December 2013; 41 (6): 1483–1488. doi: https://doi.org/10.1042/BST20130126
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