It is now becoming largely accepted that the non-coding portion of the genome, rather than its coding counterpart, is likely to account for the greater complexity of higher eukaryotes. Moreover, non-coding RNAs have been demonstrated to participate in regulatory circuitries that are crucial for development and differentiation. Whereas the biogenesis and function of small non-coding RNAs, particularly miRNAs (microRNAs), has been extensively clarified in many eukaryotic systems, very little is known about the long non-coding counterpart of the transcriptome. In the present review, we revise the current knowledge of how small non-coding RNAs and lncRNAs (long non-coding RNAs) impinge on circuitries controlling proper muscle differentiation and homoeostasis and how their biogenesis is regulated. Moreover, we provide new insights into an additional mechanism of post-transcriptional regulation mediated by lncRNAs, which, acting as miRNA ‘sponges’, have an impact on the distribution of miRNA molecules on their targets with features similar to those described for ceRNAs (competing endogenous RNAs).
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August 2013
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Conference Article|
July 18 2013
Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy
Shyam Twayana;
Shyam Twayana
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
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Ivano Legnini;
Ivano Legnini
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
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Marcella Cesana;
Marcella Cesana
1
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
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Davide Cacchiarelli;
Davide Cacchiarelli
2
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
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Mariangela Morlando;
Mariangela Morlando
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
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Irene Bozzoni
Irene Bozzoni
3
*Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy
†Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy
3To whom correspondence should be addressed (emailirene.bozzoni@uniroma1.it).
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Publisher: Portland Press Ltd
Received:
December 13 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (4): 844–849.
Article history
Received:
December 13 2012
Citation
Shyam Twayana, Ivano Legnini, Marcella Cesana, Davide Cacchiarelli, Mariangela Morlando, Irene Bozzoni; Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy. Biochem Soc Trans 1 August 2013; 41 (4): 844–849. doi: https://doi.org/10.1042/BST20120353
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