Protein kinases play a pivotal role in regulating many aspects of biological processes, including development, differentiation and cell death. Within the kinome, 48 kinases (~10%) are classified as pseudokinases owing to the fact that they lack at least one conserved catalytic residue in their kinase domain. However, emerging evidence suggest that some pseudokinases, even without the ability to phosphorylate substrates, are regulators of multiple cellular signalling pathways. Among these is KSR1 (kinase suppressor of Ras 1), which was initially identified as a novel kinase in the Ras/Raf pathway. Subsequent studies showed that KSR1 mainly functions as a platform to assemble different cellular components thereby facilitating signal transduction. In the present article, we discuss recent findings regarding KSR1, indicating that it has dual activity as an active kinase as well as a pseudokinase/scaffolding protein. Moreover, the biological functions of KSR1 in human disorders, notably in malignancies, are also reviewed.
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August 2013
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Conference Article|
July 18 2013
The dual function of KSR1: a pseudokinase and beyond
Hua Zhang;
Hua Zhang
1
1Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, U.K.
1Correspondence may be addressed to either of these authors (emailh.zhang10@imperial.ac.uk or g.giamas@imperial.ac.uk).
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Chuay Yeng Koo;
Chuay Yeng Koo
1Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, U.K.
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Justin Stebbing;
Justin Stebbing
1Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, U.K.
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Georgios Giamas
Georgios Giamas
1
1Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, U.K.
1Correspondence may be addressed to either of these authors (emailh.zhang10@imperial.ac.uk or g.giamas@imperial.ac.uk).
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Publisher: Portland Press Ltd
Received:
April 04 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (4): 1078–1082.
Article history
Received:
April 04 2013
Citation
Hua Zhang, Chuay Yeng Koo, Justin Stebbing, Georgios Giamas; The dual function of KSR1: a pseudokinase and beyond. Biochem Soc Trans 1 August 2013; 41 (4): 1078–1082. doi: https://doi.org/10.1042/BST20130042
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