Understanding the molecular mechanisms underlying cardiac development and growth has been a longstanding goal for developing therapies for cardiovascular disorders. The heart adapts to a rise in its required output by an increase in muscle mass and alteration in the expression of a large number of genes. However, persistent stress diminishes the plasticity of the heart, consequently resulting in its maladaptive growth, termed pathological hypertrophy. Recent developments suggest that the concomitant genome-wide remodelling of the gene expression programme is largely driven through epigenetic mechanisms such as post-translational histone modifications and DNA methylation. In the last few years, the distinct functions of histone modifications and of the enzymes catalysing their formation have begun to be elucidated in processes important for cardiac development, disease and cardiomyocyte proliferation. The present review explores how repressive histone modifications, in particular methylation of H3K9 (histone H3 Lys9), govern aspects of cardiac biology.
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June 2013
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Conference Article|
May 23 2013
Epigenetics in the heart: the role of histone modifications in cardiac remodelling
Asmita Tingare;
Asmita Tingare
1
*Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K.
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Bernard Thienpont;
Bernard Thienpont
1
*Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K.
†Laboratory of Translational Genetics, Vesalius Research Center, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
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H. Llewelyn Roderick
H. Llewelyn Roderick
2
*Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K.
2To whom correspondence should be addressed (emailllewelyn.roderick@babraham.ac.uk).
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Publisher: Portland Press Ltd
Received:
February 01 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (3): 789–796.
Article history
Received:
February 01 2013
Citation
Asmita Tingare, Bernard Thienpont, H. Llewelyn Roderick; Epigenetics in the heart: the role of histone modifications in cardiac remodelling. Biochem Soc Trans 1 June 2013; 41 (3): 789–796. doi: https://doi.org/10.1042/BST20130012
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