Understanding the mechanism of DNA extension in nanochannels is necessary for interpretation of experiments in nanofluidic channel devices that have been conducted recently with both linear and ring chains. The present article reviews the situation with linear chains and analyses the experimental results and simulations for channel-induced extension (linearization) of ring chains. Results for confined rings indicate a transition between moderate and strong confinement similar to that of linear chains. Owing to stronger self-avoidance in confined rings, the transition and chain extension is shifted relative to linear DNA. We suggest that a relationship similar to that used for the extension of linear chains may also be used for circular DNA.
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April 2013
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Conference Article|
March 21 2013
Comparison of linear and ring DNA macromolecules moderately and strongly confined in nanochannels
Zuzana Benková;
Zuzana Benková
*Polymer Institute, Slovak Academy of Sciences, Dúbravská cesta 9, 842 36 Bratislava, Slovakia
†REQUIMTE, Chemistry Department, University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal
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Peter Cifra
Peter Cifra
1
*Polymer Institute, Slovak Academy of Sciences, Dúbravská cesta 9, 842 36 Bratislava, Slovakia
1To whom correspondence should be addressed (emailcifra@savba.sk).
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Publisher: Portland Press Ltd
Received:
October 24 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (2): 625–629.
Article history
Received:
October 24 2012
Citation
Zuzana Benková, Peter Cifra; Comparison of linear and ring DNA macromolecules moderately and strongly confined in nanochannels. Biochem Soc Trans 1 April 2013; 41 (2): 625–629. doi: https://doi.org/10.1042/BST20120279
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