PD (Parkinson's disease) is a neurodegenerative disorder caused by loss of dopamine-generating cells in the substantia nigra. The implication of genetic factors in the aetiology of PD has an essential importance in our understanding of the development of the disease. Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene cause late-onset PD with a clinical appearance indistinguishable from idiopathic PD. Moreover, LRRK2 has been associated with the process of autophagy regulation. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD.
Skip Nav Destination
Article navigation
October 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
September 19 2012
Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease
José M. Bravo-San Pedro;
José M. Bravo-San Pedro
1
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
Search for other works by this author on:
Rubén Gómez-Sánchez;
Rubén Gómez-Sánchez
1
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
Search for other works by this author on:
Mireia Niso-Santano;
Mireia Niso-Santano
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
Search for other works by this author on:
Elisa Pizarro-Estrella;
Elisa Pizarro-Estrella
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
Search for other works by this author on:
Rosa A. González-Polo;
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
3Correspondence may be addressed to either of these authors (emailrosapolo@unex.es or jfuentes@unex.es).
Search for other works by this author on:
José M. Fuentes
1Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y TO, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, CP 10003, Cáceres, Spain
3Correspondence may be addressed to either of these authors (emailrosapolo@unex.es or jfuentes@unex.es).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 12 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (5): 1129–1133.
Article history
Received:
April 12 2012
Citation
José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Rosa A. González-Polo, José M. Fuentes; Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease. Biochem Soc Trans 1 October 2012; 40 (5): 1129–1133. doi: https://doi.org/10.1042/BST20120095
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.