Interest in studying the biology of LRRK2 (leucine-rich repeat kinase 2) started in 2004 when missense mutations in the LRRK2 gene were linked to an inherited form of Parkinson's disease with clinical and pathological presentation resembling the sporadic syndrome. LRRK2 is a complex molecule containing domains implicated in protein interactions, as well as kinase and GTPase activities. The observation that the common G2019S mutation increases kinase activity in vitro suggests that altered phosphorylation of LRRK2 targets may have pathological outcomes. Given that protein kinases are ideal targets for drug therapies, much effort has been directed at understanding the role of LRRK2 kinase activity on disease onset. However, no clear physiological substrates have been identified to date, indicating that much research is still needed to fully understand the signalling pathways orchestrated by LRRK2 and deregulated under pathological conditions.
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October 2012
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Conference Article|
September 19 2012
Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease
Elisa Greggio
Elisa Greggio
1
1Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35121 Padova, Italy
1emailelisa.greggio@unipd.it
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Publisher: Portland Press Ltd
Received:
March 07 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (5): 1058–1062.
Article history
Received:
March 07 2012
Citation
Elisa Greggio; Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease. Biochem Soc Trans 1 October 2012; 40 (5): 1058–1062. doi: https://doi.org/10.1042/BST20120054
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