Diverse aetiologies result in significant deviation from homoeostasis in the kidney, leading to CKD (chronic kidney disease). CKD progresses to end-stage renal disease principally as a result of renal fibrosis, although the molecular mechanisms underlying this fibrotic process are still poorly understood. miRNAs (microRNAs) are a recently discovered family of endogenous short single-stranded RNAs that regulate global gene expression at the post-transcriptional level. The recent findings from our laboratory and others discussed in the present review outline pleiotropic roles for miR-192 in renal homoeostasis and in the fibrotic kidney. We describe miR-192-driven anti-and pro-fibrotic effects via the repression of ZEB1 and ZEB2 (zinc finger E-box-binding homeobox proteins 1 and 2), resulting in changes in extracellular matrix deposition and cell differentiation.
Skip Nav Destination
Article navigation
August 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 20 2012
Pleiotropy of microRNA-192 in the kidney
Robert H. Jenkins;
Robert H. Jenkins
1
*Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K.
1To whom correspondence should be addressed (emailjenkinsrh2@cf.ac.uk).
Search for other works by this author on:
John Martin;
John Martin
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
Search for other works by this author on:
Aled O. Phillips;
Aled O. Phillips
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
Search for other works by this author on:
Timothy Bowen;
Timothy Bowen
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
Search for other works by this author on:
Donald J. Fraser
Donald J. Fraser
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 19 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (4): 762–767.
Article history
Received:
March 19 2012
Citation
Robert H. Jenkins, John Martin, Aled O. Phillips, Timothy Bowen, Donald J. Fraser; Pleiotropy of microRNA-192 in the kidney. Biochem Soc Trans 1 August 2012; 40 (4): 762–767. doi: https://doi.org/10.1042/BST20120085
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.