The steroid hormone oestrogen is central to normal female physiology, reproduction and behaviour, through its effects on cellular processes including cell proliferation and cell survival. The effects of oestrogen are mediated by nuclear ERs (oestrogen receptors). ER status is important for the development, progression and treatment of breast cancer. miRNAs (microRNAs) are small non-coding RNAs that bind the 3′-UTR (untranslated region) of target mRNAs to reduce their stability and/or translation. miRNAs participate in oestrogen signalling by regulating oestrogen-responsive genes and pathways. Interestingly expression and maturation of miRNAs can also be regulated by ER signalling at multiple levels. In addition to regulating the expression of miRNAs at the transcriptional level, ER appears to be able to regulate the biogenesis of miRNAs. In the present review, we summarize recent findings on miRNA biogenesis and describe various mechanisms by which oestrogen signalling can modulate the production of miRNAs.
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August 2012
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Conference Article|
July 20 2012
Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat
Ananya Gupta;
Ananya Gupta
*School of Medicine (Pathology), Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
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Emer Caffrey;
Emer Caffrey
*School of Medicine (Pathology), Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
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Grace Callagy;
Grace Callagy
*School of Medicine (Pathology), Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
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Sanjeev Gupta
Sanjeev Gupta
1
*School of Medicine (Pathology), Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
†Apoptosis Research Centre, National University of Ireland Galway, Galway, Ireland
1To whom correspondence should be addressed (emailsanjeev.gupta@nuigalway.ie).
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Publisher: Portland Press Ltd
Received:
December 02 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (4): 752–758.
Article history
Received:
December 02 2011
Citation
Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta; Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat. Biochem Soc Trans 1 August 2012; 40 (4): 752–758. doi: https://doi.org/10.1042/BST20110763
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