Bionanotechnology seeks to modify and design new biopolymers and their applications and uses biological systems as cell factories for the production of nanomaterials. Molecular self-assembly as the main organizing principle of biological systems is also the driving force for the assembly of artificial bionanomaterials. Protein domains and peptides are particularly attractive as building blocks because of their ability to form complex three-dimensional assemblies from a combination of at least two oligomerization domains that have the oligomerization state of at least two and three respectively. In the present paper, we review the application of polypeptide-based material for the formation of material with nanometre-scale pores that can be used for the separation. Use of antiparallel coiled-coil dimerization domains introduces the possibility of modulation of pore size and chemical properties. Assembly or disassembly of bionanomaterials can be regulated by an external signal as demonstrated by the coumermycin-induced dimerization of the gyrase B domain which triggers the formation of polypeptide assembly.
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August 2012
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Conference Article|
July 20 2012
Functional self-assembling polypeptide bionanomaterials
Tibor Doles;
Tibor Doles
*Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia
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Sabina Božič;
Sabina Božič
*Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia
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Helena Gradišar;
Helena Gradišar
*Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia
†EN-FIST Centre of Excellence, Ljubljana, Slovenia
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Roman Jerala
Roman Jerala
1
*Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia
†EN-FIST Centre of Excellence, Ljubljana, Slovenia
‡Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia
1To whom correspondence should be addressed (emailroman.jerala@ki.si).
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Publisher: Portland Press Ltd
Received:
February 01 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (4): 629–634.
Article history
Received:
February 01 2012
Citation
Tibor Doles, Sabina Božič, Helena Gradišar, Roman Jerala; Functional self-assembling polypeptide bionanomaterials. Biochem Soc Trans 1 August 2012; 40 (4): 629–634. doi: https://doi.org/10.1042/BST20120025
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